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More info. The Baltimore Classification System is a scheme for classifying viruses based on the type of genome and its replication strategy. The system was developed by David Baltimore. Viruses do not contain a complete system for protein translation; therefore, every virus is dependent on host translational machinery. The Baltimore system is based on how viruses use that machinery.

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The Baltimore Classification System initially included six classes of viruses. However, a seventh class was added to accommodate the gapped DNA genome of Hepadnaviridae hepatitis B virus.

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A double stranded DNA virus enters the host nucleus before it begins to replicate. It makes use of the host polymerases to replicate its genome, and is therefore highly dependent on the host cell cycle.

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The cell must therefore be in replication for the virus to replicate. Most ssDNA viruses have circular genomes and replicate mostly within the nucleus by a rolling circle mechanism. Double stranded RNA viruses replicate in the core capsid in the host cell cytoplasm and do depend as heavily on host polymerases as DNA viruses. The genomes of Class III viruses may be segmented, and unlike viruses with more complex translation, each gene codes for only one protein.

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They are further divided into viruses with polycistronic mRNA and those with complex transcription. Polycistronic mRNA is translated into a polyprotein that is subsequently cleaved to form separate proteins.

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Viruses with complex transcription use ribosomal frameshifting and proteolytic processing to produce multiple proteins from the same gene sequences. Class V viruses have a negative-sense RNA genome, meaning they must be transcribed by a viral polymerase to produce a readable strand of mRNA. The genomes of Class V viruses may be segmented or non-segmented.

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The RNA is converted to DNA by reverse transcriptase and then the DNA is spliced into the host genome for subsequent transcription and translation using the enzyme integrase. The dsDNA genome is gapped, and subsequently filled in to form a closed circle serving as a template for production of viral mRNA.

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Catherine Shaffer is a freelance science and health writer from Michigan. She has written for a wide variety of trade and consumer publications on life sciences topics, particularly in the area of drug discovery and development.

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She holds a Ph. She also writes and publishes fiction, and in her free time enjoys yoga, biking, and taking care of her pets. Shaffer, Catherine.

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In this interview, we spoke to Dr. Akpaka Kalu, the World Health Organization's team leader for malaria in Africa, about the groundbreaking malaria vaccine rollout announcement. News-Medical spoke to Dr. Aryn Gittis about her latest research into Parkinson's disease and how deep brain stimulation could be used to help treat it.

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News-Medical speaks to Professor Tomohiro Kurosaki about how he has developed a new vaccine approach that could prevent future pandemics. Accept Cookie Settings. By Dr. Catherine Shaffer, Ph. Reviewed by Afsaneh Khetrapal, BSc. Sources: Simplifying virus classification: the Baltimore system Expression of animal virus genomes Hepatitis B virus taxonomy and hepatitis B virus genotypes [Further reading: virology, virus vector, le. Written by Dr. Catherine Shaffer Catherine Shaffer is a freelance science and health writer from Michigan.

Class I: Double stranded DNA (dsDNA) viruses

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Citations Please use one of the following formats to cite this article in your essay, paper or report: APA Shaffer, Catherine. MLA Shaffer, Catherine. Chicago Shaffer, Catherine.

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Harvard Shaffer, Catherine. Suggested Reading. Supercoiling and looping can transmit mechanical stress along the DNA backbone, research shows. Study may help investigate the role of gut virome in health and disease.

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Research may lead to breakthroughs in combating cancer drug resistances. The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.

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Post a new comment. Study uncovers how novel coronavirus disrupts normal cell defenses to hijack human host cells.

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Study discloses molecular mechanism of oligodendrocyte myelination by osteocalcin in the CNS. Ants could offer new clues to human brain evolution. Honeybees increase social distancing in response to a common parasite. Lactoferrin supplements could be used as adjunct for COVID and other respiratory tract infections. Akpaka Kalu In this interview, we spoke to Dr.

Aryn Gittis News-Medical spoke to Dr. A new vaccine approach that could prevent future pandemics Professor Tomohiro Kurosaki News-Medical speaks to Professor Tomohiro Kurosaki about how he has developed a new vaccine approach that could prevent future pandemics. Types of Microbes.

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The Global Spread of Antibiotic Resistance. Production of Biopolymers by Microorganisms. Latest Life Science News.

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